Application of Box-Behnken Design for Formulation Parameters of Eslicarbazepine Tablets

Current research has been done to develop statistically and optimized immediate release tablets for eslicarbazepine. Nineteen formulations of eslicarbazepine acetate are prepared by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed study how selected independent variables affect dependent responses. After the initial test, items were as follows; polyvinylpyrrolidone (A), tapioca starch (B) galbanum gum (C). Responses measure time disintegration (Y1) in vitro drug 45 min (Y2). In accordance with variables, different established lowest, highest middle tested. predicted formula formulated statistical consisted polyvinylpyrrolidone, optimum 2.49, 2.77 3 respectively.